Some individuals have variations in a single copy of the MC1R gene in each cell that causes the gene to be turned off (deactivated). This sort of genetic change is described as loss-of-operate. For these individuals, eumelanin production is lower, whereas pheomelanin production is greater, so that they have strawberry blond, auburn, or pink hair. In a fair smaller proportion of individuals, each copies of the MC1R gene in each cell have loss-of-operate modifications, and the melanin-manufacturing pathway produces solely the pheomelanin pigment. The hair of those individuals is almost at all times very pink. Even when the melanin-production pathway is making eumelanin, changes in different genes can cut back the amount of eumelanin produced. These changes lead to blond hair.
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